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Objective: To summarize and compare the main traditional Chinese medicineTCMsyndromes of Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2SARS-CoV-2 carriers to provide references for the syndrome evolution and syndrome differentiation of SARS-CoV-2 infection. Method(s):The TCM medical records of imported and local cases of infection with Delta and Omicron variants of SARS-CoV-2 in Changsha since September 23,2021 to March 27,2022 were collected,including 18 Delta variant cases and 36 Omicron variant cases. Their TCM diagnosis information and TCM pathogenesis were analyzed and compared. Result(s): The common manifestations in Delta variant cases were cough,fever,chest distress/shortness of breath,sore muscles,nausea,dry mouth,dry or sore throat,thick and greasy tongue coating,and rapid and slippery pulse. The predominant pathogenesis was dampness-heat in the upper-energizer and heat stagnation in the lesser Yang combined with dampness. The occurrence of chest distress/shortness of breath,greasy tongue coating,slippery pulse,and the proportion of dampness-heat in the upper-energizer syndrome were higher in Delta variant cases than in Omicron variant cases P<0.05. The common manifestations in Omicron variant cases were itchy and sore throat,nasal congestion,running nose,fever,mild aversion to cold,dry mouth,dizziness,slightly reddish tongue with thin white coating,and rapid or wiry pulse. The predominant pathogenesis was wind-dryness invading defensive exterior,and heat stagnation in the lesser Yang. The occurrence of white-coated tongue and the proportion of wind-dryness invading defensive exterior syndrome were higher in Omicron variant cases than in Delta variant casesP<0.05. Conclusion(s): There are certain differences in TCM syndromes and the corresponding pathogenesis between Delta variant and Omicron variant cases in Changsha,Hunan. The Delta variant of SARS-COV-2 tends to induce dampness-heat syndrome, whereas Omicron variant infection tends to elicit wind-dampness syndrome,which is expected to provide a reference for the pathogenesis evolution of SARS-COV-2 infection.Copyright © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.
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Objective: This study focused on the systematic literature measurement and visual analysis of treating COVID-19 with combined Chinese and Western medicine to explore the development status, research hot spots and trends, and cutting-edge dynamics. It provides data, information support, and development references for treating COVID-19with combined Chinese and Western medicine. Methods: Three major databases of China National Knowledge Infrastructure(CNKI), Wanfang Data, and China Science and Technology Journal Database were used as data sources to retrieve the relevant literature on the combined Chinese and Western medicine for the treatment of COVID-19 from March2019 to March 2022. Statistical analysis was performed using bibliometric methods and CiteSpace software. Visual analysis was performed on publishing trends, research institution cooperation, author cooperation, keyword co-occurrence and clustering, and research hotspots. Results: A total of 476 articles were included in this study, with the largest number published in 2020. Statistical analysis of published units showed that the cooperative relationship between institutions was discrete, indicating that the research on treating novel coronavirus with combined Chinese and western medicine was extensive. Hot spots in the research were mainly reflected in four aspects:coronavirus, diagnosis and treatment plan, combined Chinese and Western medicine, and epidemic prevention and control. Conclusion: The research theme of treating COVID-19 with combined Chinese and Western medicine dynamically changes with the epidemic development, which is guided by clinical efficacy. It mainly focuses on the formulation of diagnosis and treatment plans. The cooperation between authors and institutions is insufficient, and communication needs to be further strengthened.
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Compound Qinlan Oral Liquid (,CQOL) is derived from Yinqiao San (), which is composed of Jinyinhua (Lonicerae Japonicae Flos), Huangqin (Scutellariae Radix), Lianqiao (Forsythiae Fructus) and Banlangen (Isatidis Radix). It is a common clinical herbal medicine for clearing heat and detoxification, and has antiviral effects. By reviewing the active ingredients of CQOL and the research progress on its anti-influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficacy, with view to providing a basis for the clinical use of CQOL in treatment of respiratory diseases caused by SARS-CoV-2.Copyright © 2023 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.
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The aim of the present research is to highlight whether there exist any diversification opportunities from investing in developed and developing countries' Shariah-compliant and non-Shariah-compliant stock markets during global financial crisis (GFC) and the COVID-19 pandemic periods. For this purpose, we employ daily data for both Shariah and non-Shariah indices from 29 October 2007 to 31 December 2021. The study uses multivariate GARCH-DCC and wavelet approaches to examine if there exist diversification opportunities in the selected markets. Evidence from this study shows that although the developing markets' stock returns experience high volatility of a similar degree, the conventional indices of Malaysia have the highest volatility among them. This shows that Shariah indices have less exposure to risk and higher possibilities of diversification compared to their conventional counterparts. Regarding developed markets, the Japanese conventional index and the U.S. Shariah indices are more volatile compared to other indices in the market. Moreover, the results of the wavelet power spectrum show significant and higher volatility during the COVID-19 pandemic rather than the GFC. Similarly, the Chinese conventional market experienced minimum variance during the GFC and COVID-19 pandemic period. On the other hand, the results of wavelet-coherence transform indicate that the Japanese Shariah-based market offered better portfolio opportunities for U.S. traders during the GFC and the COVID-19 pandemic periods. Hence, opportunities for investment in this selected market are basically close to zero. Therefore, investors should carefully choose which stocks they can include in their investment portfolio. © 2023 by the authors.
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This paper presents the experiences and perspectives of two Yorkville University faculty members teaching quantitative and non-quantitative courses to BBA students remotely and online during the COVID-19 pandemic. The authors discuss new issues faced while teaching online during the crisis. Most universities have shifted their existing courses to the online remote mode of delivery without making any changes to the course design. This study examines teaching differences for quantitative and non-quantitative courses online with a view to make recommendations based on our teaching experiences for transitioning such courses to remote synchronous delivery online. This paper also explores new methods that have been applied during online teaching while conducting different assessments (e.g., quizzes and exams). The authors share their challenges and issues based on two specific courses - Statistics for Business and Introduction to Marketing, which are typical examples of quantitative and non-quantitative courses. The paper suggests teaching approaches and how to conduct assessments online for these types of courses. These recommendations invite further discussion and research into online teaching. © Springer Nature Switzerland AG 2021. All rights reserved.
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Despite the widespread use of distance learning during the coronavirus disease-2019 (COVID-19) pandemic, little is known about the developmental appropriateness of this instructional format for preschoolers, particularly when implemented in inclusive settings. The current research was implemented in a university-affiliated, state-funded inclusive preschool classroom focused on autism spectrum disorder (ASD) where parents were given the option to enroll in a full distance program (FDP) during the first 9 weeks of the 2020/21 school year. Parents of four children, including two children with ASD, selected the FDP option. Synchronous whole group, small group, and individual online sessions were recorded using screen capture and coded for children's maintained attention and directed communication. Further, parents and teachers completed exit interviews or a focus group, which were transcribed and analyzed using qualitative research methods. This is the first study to use observational methods to measure child engagement during preschool FDP sessions. Results from this mixed-method multiple case study paint a rich picture of both opportunities and limitations inherent in distance learning when implemented in inclusive preschool settings. General conclusions, future directions, and study limitations are discussed.
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COVID-19 curtailed a significant amount of research in the field, forcing social scientists to consider the future of fieldwork. Netnography seems to offer a covid-resistant alternative to traditional fieldwork methods. This paper expands knowledge of the netnographic approach, focusing on a study of spirituality in international volunteer tourists' experiences. It explores the potential of netnography as a research tool within the context of ongoing concerns around the viability and sustainability of physically travelling to collect data. As such, this paper presents a critical, reflective analysis of the main author's experience in conducting netnographic research during the pandemic, presenting the challenges and limitations, as well as the benefits of the method.
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The Covid-19 pandemic revealed a complex health problem for people and national health systems. Faced with the initial ignorance of the behavior of the SARS-COV-2 virus in populations, people turned to relief and alternative medicines. In Ecuador, the use of traditional or western medicine and the systematic approach of people to conventional medicine are evident realities. Our work aimed to assess the knowledge, attitudes and practices regarding Covid-19 and the use of formal and traditional medicine to treat the disease or contagion. An open, personal and confidential survey was carried out, with 158 questions on general data, ethnicity, health status, covid-19 tests, use of self-medication, use of medicinal plants or other chemical products, and use of antibiotics or antiparasitics, among other data. In the control of the patients, six months after finishing the survey, they were asked about the acceptance of the vaccine and the decision to be vaccinated or not. The results in 3,000 persons (50% female and 50% male) show frequent use of alternative or traditional medicine, even in health personnel or university studies. The study's conclusions reflect that people choose any of the therapies they have access to and even mix traditional treatments with traditional ones that are unproven or toxic. © 2022 by the authors.
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Background: "Long COVID" or "post-COVID conditions" describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID-19). However, there is a paucity of published reports on its treatment. Method(s): This retrospective cohort study included adult, non-hospitalized patients with COVID-19 symptoms at least one month after the onset who had been examined at the isolation facility in Miyagi prefecture between October 2020 and September 2021. Result(s): In total, 70 patients with a median age of 46 (21-69) years were included, and 37 were women (52.9%). The median time from onset to the end of treatment was 46 (28-396) days. Thirty-eight patients (53.5%) showed improvement in all symptoms, while four (5.7%) did not recover within the study period. The symptoms at six months with high residual rates were dizziness (33.3%), fatigue (14.3%), myalgia (14.3%), abdominal discomfort (14.3%), and taste dysfunction (11.8%). For treatment of prolonged symptoms, formulae of Kampo medicine (Japanese traditional medicine) were used alone or in combination with Western medications in 76%, 66%, 53%, and 66% of patients at 1-2 months, 2-3 months, 3-6 months, and over 6 months respectively. Kampo formulae with anti-inflammatory effects were used in the early period;however, tonifying formulae and blood stasis-resolving formulae were used in the late period. Conclusion(s): Non-hospitalized patients with COVID-19 may suffer from persistent symptoms after the acute phase of infection. For the management of long COVID, a comprehensive and holistic approach is needed. Kampo medicine should be considered as a treatment option for long COVID.Copyright © 2023 The Authors. Traditional & Kampo Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Oriental Medicine and Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine.
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African traditional medicine is one of the oldest forms of health-care system in the continent that has continued to be relevant. It is usually holistic, treating mind and body, and includes aromatherapy, bone setting, circumcision, herbs, homeopathy massaging, spiritual therapies, maternity care, psychiatric care, music therapy, and many more. It is a very old and culturally informed method of health management that humans have used against diseases that have threatened existence. More than 60,000 of the world's higher plant species can be found in sub-Saharan Africa and the Indian Ocean Islands. These are about one-fourth of the global total and less than the 8% of the medicinal plants sold internationally from Africa. This scarcity could be due to lack of data on the traditional uses of many African plants as the knowledge is transferred orally by storytellers and traditional healers though in recent times, there are some information in print. Immunomodulation is seen as an essential feature of immunotherapy whereby immune responses are provoked, heightened, decreased, or avoided. Immune responses have been observed to be either cellular co-receptor expression, class switching, cytokine secretion, histamine release, immunoglobulin secretion, lymphocyte expression, or phagocytosis. Immune system dysfunction is responsible for various diseases like allergies, asthmas, arthritis, cancers, and infectious diseases. So modulation of immune responses is required in controlling diseases. This is requisite nowadays because of the upsurge of infectious diseases like superbugs caused by Multi-Resistant Staphylococcus aureus (MRSA) and the coronavirus (COVID-19) plus other emerging diseases. The historical view of African Traditional Medicine (ATMs) will be discussed from the point of view of specific plants used for immunomodulation in the ATMs and their efficacies following the trend of use and development of herbal medicines from crude formulations to refined dosage forms and procedures over time. Most of the ATMs are prepared as tonics and bitters to heighten and keep up immune defenses. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
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As the need for virtual instruction increased due to the COVID-19 pandemic, teachers faced changes in the way they had to instruct students. This sudden change impacted the delivery of information by middle school teachers who had been accustomed to the traditional (face-to-face) method of instructing their students with disabilities. This study was designed to explore teachers' perspectives on the challenges facing middle school students with disabilities in a virtual classroom during the COVID-19 pandemic. Three research questions guided the study: (a) What were teachers' perspectives on their preparation to deliver virtual instruction? (b) What strategies were implemented to serve students with disabilities in the virtual classroom?(c) What were teachers' perspectives on the benefits and challenges of virtual instruction for students with disabilities? The researcher used data from a demographic survey and interview questions from 15 special education and regular elementary, middle, and high school teachers of students with disabilities to explore the teachers' perspectives on the transition from traditional instruction to virtual instruction. Three themes evolved: Professional Development/Training in technology and adapting virtual learning to students with disabilities, Strategies to better assist these students in virtual learning, and Challenges and Benefits of teachers' transition from traditional to virtual instruction. The results of this study showed a need for professional training to provide new strategies to assist educators as they transition from traditional to virtual instruction. The study also revealed that teachers faced challenges while instructing students virtually, although teachers acknowledged some benefits. Study implications were that teachers found the transition difficult and encountered many problems with their students not experienced in the traditional classroom. Further research is needed with larger populations to explore teachers' transitions from traditional to virtual instruction, their needs for professional development and training, and means of support for students with disabilities. (PsycInfo Database Record (c) 2023 APA, all rights reserved)
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The Corona Virus Disease 2019 (COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing a system that can fully digitalize the medical data of each individual and make it readily accessible for both the patient and health worker at any point in time. Moreover, there are also no ways for the government to identify the legitimacy of a particular clinic. This study merges modern technology with traditional approaches, thereby highlighting a scenario where artificial intelligence (AI) merges with traditional Chinese medicine (TCM), proposing a way to advance the conventional approaches. The main objective of our research is to provide a one-stop platform for the government, doctors, nurses, and patients to access their data effortlessly. The proposed portal will also check the doctors' authenticity. Data is one of the most critical assets of an organization, so a breach of data can risk users' lives. Data security is of primary importance and must be prioritized. The proposed methodology is based on cloud computing technology which assures the security of the data and avoids any kind of breach. The study also accounts for the difficulties encountered in creating such an infrastructure in the cloud and overcomes the hurdles faced during the project, keeping enough room for possible future innovations. To summarize, this study focuses on the digitalization of medical data and suggests some possible ways to achieve it. Moreover, it also focuses on some related aspects like security and potential digitalization difficulties.Copyright © 2022 Digital Chinese Medicine
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As described in Saha and Chakrabarti (South Asian Survey 28(1):111-132, 2021: 112), "COVID-19 has firmly established itself as the single largest security disrupter of this century in the non-traditional sense. It has necessitated a recalibration of securitisation framework.…" The impact of the COVID-19 pandemic certainly illustrates the transnational nature of today's security landscape. Similarly, events such as the WannaCry cyber-attack, global terrorism, serious and organized crime, disease vectors, and natural disasters create challenges that affect both global and national security interests. Such events are shaping the security calculus across dimensions such as health security, economic security, food security, and energy security emerging as interrelated concepts that characterize the security landscape as complex. The increased transnational flow of people, goods, money, and information as products of "globalization” has also changed the security landscape in terms of the "globalization” of risks. This transnational/transborder nature of security challenges our traditional views of national security characterized by state-based, military dimensions. The non-traditional security calculus thereby emerges as part of the security landscape that can often have significant national security impacts through the implications associated with systemic risks. Outstanding scholarly work has been presented on the topic of non-traditional security through the lens of International Relations and Contemporary Security Studies (e.g., see Collins, Contemporary security studies. Oxford University Press, Oxford, 2013). This chapter presents non-traditional security through a risk-centric lens and explores the notion of systemic risk as part of the security calculus. COVID-19 will be used as an illustrative example of a shock to societal systems that reveals systemic risks, vulnerabilities, and impacts across the non-traditional security domains. © Springer Nature Switzerland AG 2022.
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[] Atherosclerosis (As) is the pathological basis of coronary heart disease, and vascular endothelial injury is the initiating factor of coronary atherosclerosis. Vascular endothelial cells are a single layer of cells located in the inner layer of blood vessels and regulates exchanges between the blood stream and the surrounding tissues, and their integrity is very important. Many active monomers and the derivatives in natural products of traditional Chinese medicine modulate the function of endothelial cells by intervening oxidative stress, regulating the release of vasoactive substances, reducing inflammation, and equilibrating coagulation and anticoagulant system. They have the advantages of multi-pathway, multi-link and multi-target regulation in protecting from endothelial injury and attenuating atherogenesis. They have also been used to protect against corona virus disease 2019 (COVID-19) induced endothelial injury and atheroslerosis. This article reviews the research progress of the above issues in this field. © 2023, Editorial Office of Chinese Journal of Arteriosclerosis. All rights reserved.
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The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) Omicron variants BA.5.2 and BF.7 have become the main epidemic strains in China since the quarantine policy was lifted in 7th December 2022. Cough is one of the main symptoms induced by SARS-CoV-2 infection. SARS-CoV-2 infection-associated cough injuries the lung and upper respiratory tract, while the infected people cough out virus and liquid which forms virus-containing aerosols, a medium for quickly spreading. Furthermore, cough is one of primary sequelae of discharged patients in corona virus disease 2019 (COVID-19). By now, there are no efficacious drugs for treatment of upper respiratory tract infection associated cough induced by omicron. Traditional Chinese medicine (TCM) has a long history on treating cough. By reviewing the mechanisms of the occurrence of cough after SARS-CoV-2 infection, potential therapeutic targets and cough suppressant herbs with significant efficacy in clinical and basic research, we provide a reference for the treatment of cough after SARS-Cov-2 infection and a basis for the majority of infected patients to select appropriate herbs for cough relief under guidance of physicians.Copyright © 2023 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.
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Objective: Viruses are agents that can infect all kinds of living organisms, and the most important hosts are humans, animals, plants, bacteria and fungi. Viral diseases are responsible for serious morbidity and mortality worldwide, are a major threat to public health, and remain a major problem worldwide. The recently prominent Coronaviruses (CoVs) within this group belong to the Coronaviridae family, subfamily Coronavirinae, and are large (genome size 26-32 kb), enveloped, single-stranded ribonucleic acid (RNA ) viruses that can infect both animals and humans. The world has experienced three epidemics caused by betaCoVs in the last two decades: SARS in 2002-03, MERS in 2012, and COVID-19, first identified in 2019. COVID-19 continues to be our current health problem and studies on the subject continue. Result and Discussion: The term "antiviral agents" is defined in very broad terms as substances other than virus-containing vaccine or specific antibody that can produce a protective or therapeutic effect for the clearly detectable effect of the infected host. Nature has the potential to cure humanity's helplessness against viruses with many different plant species with strong antiviral effects. During the screening of plants with antiviral effects, focusing on plants used in folk medicine is of great importance in terms of maximizing the benefit to humanity - saving time and effort by dealing with valuable ancient knowledge on a scientific basis. In this review, viral diseases and the plants used in these diseases and determined to be effective are mentioned.Copyright © 2022 University of Ankara. All rights reserved.
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Higher education institutions confronted an escalating unexpected pressure to rapidly transform throughout and after the COVID-19 pandemic, by replacing most of the traditional teaching practices with online-based education. Such transformation required institutions to frequently strive for qualities that meet conceptual requirements of traditional education due to its agility and flexibility. The challenge of such electronic learning styles remains in their potential of bringing out many challenges, along with the advantages it has brought to the educational systems and students alike. This research came to shed the light on several factors presented as a predictive model and proposed to contribute to the success or failure in terms of students' satisfaction with online learning. The study took the kingdom of Jordan as a case example country experiencing online education while and after the covid -19 intensive implementation. The study used a dataset collected from a sample of over "300” students using online questionnaires. The questionnaire included "25” attributes mined into the Knime analytics platform. The data was rigorously learned and evaluated by both the "Decision Tree” and "Naive Bayes” algorithms. Subsequently, results revealed that the decision tree classifier outperformed the naïve bayes in the prediction of student satisfaction, additionally, the existence of the sense of community while learning electronically among other reasons had the most contribution to the satisfaction. Copyright © 2023 by SCITEPRESS - Science and Technology Publications, Lda. Under CC license (CC BY-NC-ND 4.0)
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Traditional villages are a valuable cultural asset that occupy an important position in Chinese traditional culture. This study focuses on 206 traditional villages in Hebei Province and aims to explore their spatial distribution characteristics and influencing factors using ArcGIS spatial analysis. The analysis shows that traditional villages in Hebei Province were distributed in clusters during different historical periods, and eventually formed three core clusters in Shijiazhuang, Zhangjiakou and Xingtai-Handan after different historical periods. Moreover, the overall distribution of traditional villages in Hebei Province is very uneven, with clear regional differences, and most of them are concentrated in the eastern foothills of the Taihang Mountains. To identify the factors influencing traditional villages, natural environmental factors, socio-economic factors, and historical and cultural factors are considered. The study finds that socio-economic and natural environmental factors alternate in the spatial distribution of traditional villages in Hebei Province. The influence of the interaction of these factors increases significantly, and socio-economic factors have a stronger influence on the spatial distribution. Specifically, the spatial distribution of traditional villages in Hebei Province is influenced by natural environmental factors, while socio-economic factors act as drivers of spatial distribution. Historical and cultural factors act as catalysts of spatial distribution, and policy directions are external forces of spatial distribution. Overall, this study provides valuable insights into the spatial distribution characteristics and influencing factors of traditional villages in Hebei Province, which can be used to develop effective strategies for rural revitalisation in China.
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Introduction: The onset and rise of COVID-19 and its sudden progression to a worldwide pandemic lead medical and dental institutes to change their way of teaching and conducting assessments to distance learning as compared to the previously applied conventional approaches. Teaching and assessment during this era have changed vastly, earlier it was solely traditional/live Objective Structured Clinical Examination (OSCE) but due to the current circumstances electronic/online OSCE (E-OSCE) method was introduced. In Pakistan also, Pakistan Medical Council (PMC) and the College of Physicians and Surgeons of Pakistan (CPSP) conducted online exams so that the scheduled exams do not get delayed. Aim(s): The main objective of this paper is to measure the reliability of an E-OSCE and to compare it with the traditional OSCE. Methodology: This was a cross-sectional study which got conducted at the Rawal Institute of Health Sciences, Islamabad. Traditional OSCEs and E-OSCEs were conducted with 71 participants including final year students and house officers. Each OSCEs had 10 stations, including one interactive station in traditional OSCE. Students' scores in both the OSCEs were collected and paired t-test was used to compare the mean scores at p<0.05. Result(s): Total number of house officers were 27 and final year students were 44. The scores of 71 participants were collected. The difference between mean scores of house officers' traditional OSCE and E-OSCE was statistically significant (p=0.000). The difference between final year students traditional OSCE and E-OSCE was also statistically significant (p=0.020). Finally, the overall difference between traditional OSCE and E-OSCE was also statistically significant (p=0.000) Practical implication: The main objective of this study was to assess the reliability of an E-OSCE and to compare whether the electronic method of conducting OSCE is more reliable than the traditional method of conducting OSCE. Conclusion(s): Despite limitations and the biases, the results of E-OSCE proved to be better than traditional OSCE. Further research needs to be conducted on E-OSCE to control the factors causing biases and limitations.Copyright © 2023 Lahore Medical And Dental College. All rights reserved.
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Since the onset of the COVID-19 pandemic, there has been a significant surge in interest of COVID-19 vaccines in particular, and other traditional vaccines in general. This strong interest is expected to continue as the industry strives to manufacture safer and more effi cacious vaccines against COVID-19 and other infectious diseases. Vaccines are a unique class of products, being biologicals that are administered to healthy individuals to prevent diseases. The equitable distribution and availability of safe, efficacious and good quality vaccines are of utmost importance in preventing and controlling infections and safeguarding public health. The continued existence of poor- quality vaccines suggests a lack of control of manufacturing, storage, distribution, and possibly, their associated regulation. Nonetheless, all these situations - whether positive or negative, present opportunities for improvements. As regulatory authorities step up efforts in regulating existing traditional vaccines, advancements in vaccine research and development churn out novel vaccines that pose further manufacturing and regulatory challenges. This manuscript provides an overview of vaccines, both traditional and novel, and strives to identify challenges in the manufacture, storage, distribution, handling and their associated regulation. It also evaluates whether current regulatory frameworks are adequate, and where applicable, recommends areas for improvements. International harmonization and convergence of national regulatory framework with the view to facilitate quicker approval of safe, efficacious and good quality vaccines, that are accessible and affordable to patients worldwide, are also explored.